In Vivo Therapeutic Gas Delivery for Neuroprotection With Echogenic Liposomes
نویسندگان
چکیده
منابع مشابه
In vivo therapeutic gas delivery for neuroprotection with echogenic liposomes.
BACKGROUND Ischemia-related neurological injury is a primary cause of stroke disability. Studies have demonstrated that xenon (Xe) may have potential as an effective and nontoxic neuroprotectant. Xe delivery is, however, hampered by lack of suitable administration methods. We have developed a pressurization-freeze method to encapsulate Xe into echogenic liposomes (Xe-ELIP) and have modulated lo...
متن کاملImaging In Vivo Therapeutic Gas Delivery for Neuroprotection With Echogenic Liposomes
Background—Ischemia-related neurological injury is a primary cause of stroke disability. Studies have demonstrated that xenon (Xe) may have potential as an effective and nontoxic neuroprotectant. Xe delivery is, however, hampered by lack of suitable administration methods. We have developed a pressurization-freeze method to encapsulate Xe into echogenic liposomes (Xe-ELIP) and have modulated lo...
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Echogenic liposomes (ELIP) are submicron-sized phospholipid vesicles that contain both gas and fluid. With antibody conjugation and drug incorporation, these liposomes can be used as novel targeted diagnostic and therapeutic ultrasound contrast agents. The utility of liposomes for contrast depends upon their stability in an acoustic field, whereas the use of liposomes for drug delivery requires...
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ژورنال
عنوان ژورنال: Circulation
سال: 2010
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.109.879338